Professor Claudia Claus

Rubella virus and novel concepts for congenital rubella embryopathy

As a biologist working in the field of virology my research focus is set on the interaction of rubella virus with its respective host cell. This efficient viral teratogen is a strictly human-specific pathogen. The cellular mechanisms leading to the impairment of human development are still unknown. As illustrated hereafter rubella virus can be teratogenic from early pregnancy on. How it could get access to the developing embryo even at these early developmental stages remains an open question.

Professor Claudia Claus

Rubella virus and novel concepts for congenital rubella embryopathy

As a biologist working in the field of virology my research focus is set on the interaction of rubella virus with its respective host cell. This efficient viral teratogen is a strictly human-specific pathogen. The cellular mechanisms leading to the impairment of human development are still unknown. As illustrated hereafter rubella virus can be teratogenic from early pregnancy on. How it could get access to the developing embryo even at these early developmental stages remains an open question.

Professor Claudia Claus

Rubella virus and novel concepts for congenital rubella embryopathy

As a biologist working in the field of virology my research focus is set on the interaction of rubella virus with its respective host cell. This efficient viral teratogen is a strictly human-specific pathogen. The cellular mechanisms leading to the impairment of human development are still unknown. As illustrated hereafter rubella virus can be teratogenic from early pregnancy on. How it could get access to the developing embryo even at these early developmental stages remains an open question.

(A) Timeline of rubella virus infection during first trimester pregnancy and (B) illustration of the implantation of the blastocyst with a hypothetical contributory role of immune cells. Reprinted from “Pluripotent stem cell-based models: a peephole into virus infections during early pregnancy,” by C. Claus, M. Jung, and J. M. Hübschen, 2020, Cells, (3): 542. doi: 10.3390/cells9030542. 
Our approach to evaluate rubella virus-associated effects on developmental pathways includes its cytopathology and immunopathology, the alterations of cellular metabolism, and its course of infection on induced pluripotent stem cells (iPSCs) as a cell culture model for the very early steps of human development.

During my study of Biological Sciences at the University of Halle-Wittenberg a lecture on viruses as pirates of a cell initiated my interest in virology. From 1999 to 2000 I was enroled at the Queen’s University of Belfast as a non-graduating student. There I attended classes in general and specialiced virology. In 2006, during my doctoral thesis, I worked as a research scholar in the laboratory of Prof. Teryl Frey at Georgia State University in Atlanta. Hereafter more recent points of the timeline of my research work are summarized.