Claudia Claus, PhD

Rubella virus and novel concepts for congenital rubella embryopathy

As a biologist working in the field of virology my research focus is set on the interaction of rubella virus with its respective host cell. This efficient viral teratogen is a strictly human-specific pathogen. The cellular mechanisms leading to the impairment of human development are still unknown. As illustrated hereafter rubella virus can be teratogenic from early pregnancy on. How it could get access to the developing embryo even at these early developmental stages remains an open question.

Claudia Claus, PhD

Rubella virus and novel concepts for congenital rubella embryopathy

As a biologist working in the field of virology my research focus is set on the interaction of rubella virus with its respective host cell. This efficient viral teratogen is a strictly human-specific pathogen. The cellular mechanisms leading to the impairment of human development are still unknown. As illustrated hereafter rubella virus can be teratogenic from early pregnancy on. How it could get access to the developing embryo even at these early developmental stages remains an open question.

Claudia Claus, PhD

Rubella virus and novel concepts for congenital rubella embryopathy

As a biologist working in the field of virology my research focus is set on the interaction of rubella virus with its respective host cell. This efficient viral teratogen is a strictly human-specific pathogen. The cellular mechanisms leading to the impairment of human development are still unknown. As illustrated hereafter rubella virus can be teratogenic from early pregnancy on. How it could get access to the developing embryo even at these early developmental stages remains an open question.

Claudia Claus, PhD

Rubella virus and novel concepts for congenital rubella embryopathy

As a biologist working in the field of virology my research focus is set on the interaction of rubella virus with its respective host cell. This efficient viral teratogen is a strictly human-specific pathogen. The cellular mechanisms leading to the impairment of human development are still unknown. As illustrated hereafter rubella virus can be teratogenic from early pregnancy on. How it could get access to the developing embryo even at these early developmental stages remains an open question.

Claudia Claus, PhD

Rubella virus and novel concepts for congenital rubella embryopathy

As a biologist working in the field of virology my research focus is set on the interaction of rubella virus with its respective host cell. This efficient viral teratogen is a strictly human-specific pathogen. The cellular mechanisms leading to the impairment of human development are still unknown. As illustrated hereafter rubella virus can be teratogenic from early pregnancy on. How it could get access to the developing embryo even at these early developmental stages remains an open question.

(A) Timeline of rubella virus infection during first trimester pregnancy and (B) illustration of the implantation of the blastocyst with a hypothetical contributory role of immune cells. Reprinted from “Pluripotent stem cell-based models: a peephole into virus infections during early pregnancy,” by C. Claus, M. Jung, and J. M. Hübschen, 2020, Cells, (3): 542. doi: 10.3390/cells9030542. 
Our approach to evaluate rubella virus-associated effects on developmental pathways includes its cytopathology and immunopathology, the alterations of cellular metabolism, and its course of infection on induced pluripotent stem cells (iPSCs) as a cell culture model for the very early steps of human development.

During my study of Biological Sciences at the University of Halle-Wittenberg a lecture on viruses as pirates of a cell initiated my interest in virology. From 1999 to 2000 I was enroled at the Queen’s University of Belfast as a non-graduating student. There I attended classes in general and specialiced virology. In 2006, during my doctoral thesis, I worked as a research scholar in the laboratory of Prof. Teryl Frey at Georgia State University in Atlanta. Hereafter more recent points of the timeline of my research work are summarized.

Timeline

2020
Mai 12

Congratulations to Maria Wald for her stipend from the Dres. Jutta & Georg Bruns-Stiftung. Maria will pursue research on Usutu virus as a joint student with Michael Sieg from the Institute of Virology, Faculty of Veterinary Medicine.

Doktorandin Frau Maria Wald
April 18

Congratulations to my student Mechthild Lorenz for successfully defending her MD thesis on rubella virus strain-specific differences in the induction of an interferon response.

Mechthild Lorenz
2018
November 16

Collaboration meeting with Giada Frascaroli from the Heinrich Pette Institute (HPI) in Hamburg. We discussed my presentation on „Exploring rubella virus and its connections to cytomegaloviurs“.

Collaboration meeting with Giada Frascaroli from the Heinrich Pette Institute (HPI) in Hamburg. We discussed my presentation on „Exploring rubella virus and its connections to cytomegaloviurs“.
November 4

Appointment as project manager according to the gene technology act

Oktober 3

Sarah Zobel and Mechthild Lorenz finished their work on their medical thesis, which contributed to our just accepted publication in viruses.

Sarah Zobel and Mechthild Lorenz finished their work on their medical thesis, which contributed to our just accepted publication in viruses.
2017
November 21

Janik Böhnke completed his master thesis on the characterization of the infection of iPSCs with coxsackievirus B3.

Janik Böhnke completed his master thesis on the characterization of the infection of iPSCs with coxsackievirus B3.
August 21

Lena Manssen has received the „Promotionspreis der Medizinischen Fakultät Leipzig“ – an award by the Medical Faculty of the University of Leipzig for her medical thesis. Congratulations!

Lena Manssen has received the „Promotionspreis der Medizinischen Fakultät Leipzig“ – an award by the Medical Faculty of the University of Leipzig for her medical thesis. Congratulations!
2014
September 4

approval of the DFG grant CL 459/3-1 „Undifferentiated and differentiating human pluripotent stem cells as in vitro model for viral alterations in early embryogenesis“

2013
Dezember 5

Election as co-chair of the workshop „Cell biology of virus infections“ for the period of 2014 until 2016.